James J Lee Selected Research

Interleukin-5 (Interleukin 5)

1/2017	Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.
1/2016	G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ.
2/2015	Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge.
4/2014	Eosinophils regulate peripheral B cell numbers in both mice and humans.
1/2014	Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis.
12/2013	Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation.
8/2012	Interleukin 5 is protective during sepsis in an eosinophil-independent manner.
1/2011	Local proliferation and mobilization of CCR3(+) CD34(+) eosinophil-lineage-committed cells in the lung.
11/2009	Mouse eosinophils possess potent antibacterial properties in vivo.
6/2007	Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma.

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James J Lee Research Topics

Disease

40	Inflammation (Inflammations) 10/2019 - 05/2002
36	Neoplasms (Cancer) 01/2022 - 01/2005
21	Asthma (Bronchial Asthma) 10/2020 - 04/2002
20	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 09/2007
19	Eosinophilia 01/2019 - 07/2004
12	Infections 01/2018 - 06/2006
10	Pneumonia (Pneumonitis) 01/2018 - 12/2002
7	Respiratory Hypersensitivity 01/2018 - 01/2003
7	Breast Neoplasms (Breast Cancer) 02/2014 - 04/2005
6	Fibrosis (Cirrhosis) 10/2015 - 06/2007
5	Eosinophilic Esophagitis 10/2019 - 10/2011
5	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 01/2017 - 04/2002
4	Necrosis 12/2016 - 06/2006
4	Ileitis 04/2016 - 05/2010
4	Colitis 04/2016 - 11/2005
3	Diarrhea 01/2018 - 05/2004
3	Colonic Neoplasms (Colon Cancer) 01/2018 - 08/2013
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2016 - 11/2008
3	Neoplasm Metastasis (Metastasis) 08/2015 - 10/2008
3	Pulmonary Fibrosis (Fibrosing Alveolitis) 11/2014 - 12/2008
3	Hyperplasia 01/2014 - 06/2007
3	Sepsis (Septicemia) 08/2012 - 01/2005
2	Triple Negative Breast Neoplasms 01/2022 - 02/2014
2	Type 2 Diabetes Mellitus (MODY) 01/2021 - 03/2012
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 11/2019 - 01/2014
2	Microsatellite Instability 11/2019 - 12/2018
2	Dermatitis 11/2019 - 12/2013
2	Rhinosinusitis 01/2019 - 10/2012
2	Hypoxia (Hypoxemia) 01/2019 - 03/2010
2	Turcot syndrome 01/2017 - 06/2015
2	Fatigue 01/2017 - 08/2007
2	Nematode Infections 10/2014 - 03/2014
2	Gastroesophageal Reflux (GERD) 10/2013 - 05/2012

Drug/Important Bio-Agent (IBA)

20	AllergensIBA 01/2018 - 04/2002
13	Interleukin-5 (Interleukin 5)IBA 01/2017 - 11/2004
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2005
10	CytokinesIBA 10/2016 - 11/2003
7	Eosinophil PeroxidaseIBA 01/2019 - 05/2004
7	OvalbuminIBA 01/2018 - 12/2002
7	ixabepilone (BMS 247550)FDA Link 02/2009 - 04/2005
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2013
6	epothilone B (EPO906)IBA 02/2009 - 04/2005
5	AntigensIBA 01/2022 - 06/2006
5	Interleukin-13IBA 01/2019 - 10/2011
5	Interleukin-10 (Interleukin 10)IBA 02/2015 - 09/2006
4	Pharmaceutical PreparationsIBA 01/2019 - 01/2013
4	Oxaliplatin (Eloxatin)FDA LinkGeneric 12/2018 - 09/2007
4	Fluorouracil (Carac)FDA LinkGeneric 01/2018 - 09/2007
4	Methacholine Chloride (Methacholine)FDA Link 01/2018 - 10/2006
4	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018 - 10/2008
4	Chemokine CCL24IBA 01/2017 - 06/2007
4	Eosinophil Granule ProteinsIBA 01/2017 - 09/2006
4	TubulinIBA 02/2009 - 04/2005
4	Taxoids (Taxanes)IBA 02/2009 - 04/2006
4	taxaneIBA 02/2009 - 12/2005
4	Epothilones (Epothilone)IBA 02/2009 - 04/2006
3	pembrolizumabIBA 01/2022 - 06/2015
3	Immune Checkpoint InhibitorsIBA 12/2018 - 06/2015
3	Irinotecan (Camptosar)FDA LinkGeneric 01/2018 - 09/2007
3	Capecitabine (Xeloda)FDA Link 01/2018 - 12/2005
3	Immunoglobulin E (IgE)IBA 01/2018 - 11/2003
3	LipidsIBA 07/2017 - 04/2007
3	Antiviral Agents (Antivirals)IBA 01/2017 - 01/2014
3	Interleukin-33IBA 12/2016 - 10/2015
3	Nitric Oxide Synthase (NO Synthase)IBA 07/2016 - 10/2014
3	Interleukin-6 (Interleukin 6)IBA 01/2016 - 08/2012
3	OxazoloneIBA 08/2015 - 11/2005
3	Interleukin-4 (Interleukin 4)IBA 02/2015 - 01/2007
2	Cetuximab (Erbitux)FDA Link 01/2021 - 11/2019
2	DNA (Deoxyribonucleic Acid)IBA 12/2020 - 09/2008
2	regorafenibIBA 11/2019 - 01/2019
2	SteroidsIBA 01/2019 - 08/2011
2	Proton Pump InhibitorsIBA 01/2019 - 02/2013
2	Oxygen (Dioxygen)IBA 01/2019 - 01/2005
2	Substance PIBA 01/2018 - 02/2015
2	Prednisone (Sone)FDA LinkGeneric 01/2018 - 03/2011
2	AutoantibodiesIBA 01/2018 - 01/2018
2	AntibodiesIBA 01/2018 - 01/2017
2	Immunoglobulin G (IgG)IBA 01/2018 - 04/2007
2	AcidsIBA 07/2017 - 08/2015
2	PeroxidasesIBA 12/2016 - 05/2002
2	Peroxidase (Myeloperoxidase)IBA 12/2016 - 03/2014
2	MucinsIBA 10/2016 - 10/2006
2	Dextrans (Dextran)FDA Link 01/2016 - 05/2004
2	ParaffinIBA 01/2016 - 06/2013
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2016 - 05/2004
2	Growth Factor ReceptorsIBA 01/2016 - 10/2007
2	Bleomycin (Blenoxane)FDA LinkGeneric 11/2014 - 12/2008
2	CollagenIBA 11/2014 - 12/2013
2	Oxidoreductases (Dehydrogenase)IBA 09/2012 - 03/2010
2	LigandsIBA 01/2011 - 03/2007
2	ChemokinesIBA 09/2010 - 11/2008
2	Monoclonal AntibodiesIBA 07/2009 - 10/2007
2	Purinergic P1 Receptors (Adenosine Receptor)IBA 12/2008 - 07/2004

Therapy/Procedure

26	Therapeutics 01/2021 - 04/2005
10	Drug Therapy (Chemotherapy) 01/2022 - 04/2006
3	Immunotherapy 11/2019 - 01/2007
3	Aftercare (After-Treatment) 08/2007 - 04/2005
2	Injections 01/2019 - 11/2016
2	Adjuvant Chemotherapy 01/2017 - 08/2013